Quinine bisulfate
Catalog No.
C8707
An antimalarial drug whose primary target is the hemoglobin metabolism pathway during the intraerythrocytic stage of Plasmodium.
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Quinine is a classic antimalarial drug whose primary target is the hemoglobin metabolism pathway during the intraerythrocytic stage of Plasmodium. Plasmodium digests hemoglobin to produce free heme, which is usually polymerized into non-toxic hemozoin within the food vacuole. Quinine accumulates in the acidic vacuole and binds to heme, blocking its polymerization, leading to the accumulation of free heme and iron‑porphyrin, causing membrane damage and oxidative stress, ultimately killing Plasmodium. It remains effective against multidrug-resistant P. falciparum, but the therapeutic window is narrow, and cardiac and central nervous system toxicity require attention.
| Storage | 4℃, stored under nitrogen, protect from light |
| M.Wt | 422.5 |
| Cas No. | 549-56-4 |
| Formula | C20H24N2O2•H2O4S |
| Chemical Name | (R)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol sulfate |
| SDF | Download SDF |
| Canonical SMILES | S(=O)(=O)(O)O.[C@@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@]3([N@@]4C[C@H](C=C)[C@](C3)(CC4)[H])[H] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |