PRGL493

PRGL493 (CAS No.: 2479378-45-3) is a synthetic small-molecule research tool classified as a selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor, suitable for biomedical research related to lipid metabolism and signal transduction as well as early-stage drug discovery applications; its biological context involves the activation of polyunsaturated fatty acids (such as arachidonic acid) into acyl?CoA and their entry into phospholipid remodeling and downstream lipid signaling networks. By blocking ACSL4-dependent arachidonoyl?CoA formation, this compound limits the supply of phospholipid substrates available for oxidative reactions, thereby modulating key pathways associated with processes such as ferroptosis susceptibility, tumor cell proliferation and migration, and the coupling of fatty acid activation with steroidogenesis; in in vitro cell systems, it typically exhibits activity in the low to mid micromolar range, manifested as inhibition of ACSL4-driven lipid metabolism and consequent attenuation of proliferation- and motility-related phenotypes in commonly used breast- and prostate-derived models; in endocrine-related models (such as Leydig tumor cells), under cyclic adenosine monophosphate stimulation conditions, it can reduce steroidogenic output, providing an experimental handle for dissecting the functional connection between lipid metabolism and steroid biosynthesis; in mouse xenograft systems in which ACSL4 participates in tumor growth, research observations of inhibited tumor growth have been reported, supporting its value as a mechanistic probe in tumor biology. Typical applications include: dissecting ferroptosis sensitivity and lipid signaling dependence in cellular and animal models, studying metastasis-related programs, and use in target validation, pathway mapping, and lead discovery screening; the concentration or dose used in specific experiments generally depends on the research objective and experimental design. This product is for laboratory research use only and is not intended for diagnostic, clinical, or any other non-research purposes.