Pinaverium bromide

Pinaverium bromide (CAS No.: 53251-94-8) is a synthetic small molecule classified as a selective gastrointestinal smooth muscle calcium channel blocker and antispasmodic research compound, primarily used in biomedical studies of gut motility regulation and visceral hypersensitivity rather than as a biologically derived metabolite, with its functional profile centered on inhibition of L type voltage dependent calcium influx in intestinal smooth muscle cells to reduce excitation contraction coupling and downstream contractile signaling linked to calcium calmodulin and myosin light chain kinase driven pathways; across published pharmacology descriptions, its activity is generally consistent with calcium channel modulation observed in the nanomolar to micromolar range depending on assay format, tissue source, and readout sensitivity, while detailed standardized potency values are not uniformly reported for all experimental systems, and in translational preclinical workflows it is commonly incorporated into in vitro smooth muscle contractility assays, enteric neuroeffector co culture models, and gastrointestinal function studies in animal models to interrogate mechanisms of spasm, pain associated motility disturbance, and diarrhea related hypercontractility, as well as to benchmark pathway selective calcium channel inhibition during lead optimization and comparator profiling in drug discovery programs focused on functional gastrointestinal biology, where the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.