Phentolamine

Phentolamine (CAS No.: 50-60-2) is an orally active selective α1 and α2 adrenergic receptor antagonist, widely used in biomedical research, especially with important value in exploring cardiovascular function and the mechanisms of erectile dysfunction. As a synthetic compound, Phentolamine reduces systemic vascular resistance and increases cardiac output by antagonizing the relaxing effects of potassium channel opener-like agents on coronary artery segments. In vitro activity levels in the nanomolar to micromolar range reveal its signaling pathways in regulating vascular responses and hemodynamics. In in vivo model studies, the effects of this compound are often used to evaluate cardiovascular responses, further elucidating its impact on vascular smooth muscle function and cardiac output. Phentolamine is an important tool in drug screening; by improving our understanding of adrenergic regulation and related cardiovascular phenomena, its concentration or dose in typical experimental applications usually varies according to the specific experimental design and research objectives.