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PF-543 Citrate

Catalog No.
A3718
SphK1 inhibitor,potent and cell-permeate
Grouped product items
SizePriceStock Qty
5mg
$83.00
In stock
10mg
$132.00
In stock
50mg
$356.00
Ship with 10-15 days
200mg
$990.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

PF-543 is a novel cell-permeant inhibitor of SphK1. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt657.73
Cas No.1415562-83-2
FormulaC33H39NO11S
SynonymsPF543 Citrate;PF 543 Citrate
Solubility≥89.4 mg/mL in DMSO; ≥28.33 mg/mL in EtOH with gentle warming and ultrasonic; ≥51.8 mg/mL in H2O with gentle warming and ultrasonic
Chemical Name[(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol;2-hydroxypropane-1,2,3-tricarboxylic acid
SDFDownload SDF
Canonical SMILESCC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

PF-543 Citrate