PF-06424439 methanesulfonate
PF-06424439 methanesulfonate is an orally effective and selective imidazole-pyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM. DGAT2 is a key enzyme in the triglyceride synthesis pathway. Inhibiting DGAT2 can reduce the synthesis of triglycerides and may thus be used in the treatment of metabolism-related diseases. PF-06424439 methanesulfonate exhibits a slow, reversible, time-dependent inhibitory effect and inhibits DGAT2 in a non-competitive mode compared with acyl-COA substrates. This unique inhibitory mechanism makes it of great significance in pharmacological research and clinical development, and it is expected to become a new drug candidate for the treatment of diseases related to lipid metabolism disorders.
| Storage | Store at -20°C for 3 years. |
| M.Wt | 536.05 |
| Cas No. | 1469284-79-4 |
| Formula | C23H30ClN7O4S |
| Solubility | Soluble in DMSO |
| Chemical Name | (R)-(1-(2-(1-(4-chloro-1H-pyrazol-1-yl)cyclopropyl)-3H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate |
| SDF | Download SDF |
| Canonical SMILES | O=C(N1CCCC1)[C@@H]2CCCN(C3=CC=C4C(NC(C5(CC5)N6N=CC(Cl)=C6)=N4)=N3)C2.CS(O)(=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
