Pertussis Toxin
Catalog No.
B7273
causes whooping cough
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Pertussis toxin (CAS: 70323-44-3) is an AB5-type protein exotoxin produced by Bordetella pertussis, the bacterium responsible for whooping cough. Mechanistically, pertussis toxin modulates host immune responses primarily via a cAMP-dependent pathway, as demonstrated by its actions on human monocyte-derived dendritic cells, influencing their maturation and cytokine production. In animal models, treatment reduces norepinephrine-induced contractions in rat mesenteric resistance arteries without notable effects on mouse tracheal contractility. Pertussis toxin serves as a research tool in immunological studies and is central to acellular pertussis vaccines designed to limit disease transmission and severity across susceptible populations.
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| Physical Appearance | Each vial, when reconstituted to 500 μL with water, contains 50 μg of pertussis toxin in 0.01 M sodium phosphate, 0.05 M sodium chloride, pH 7.0 |
| Storage | Desiccate at 4°C |
| Cas No. | 70323-44-3 |
| Solubility | Soluble in H2O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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