PBS Liposomes

To investigate the function of macrophages in a complex in vivo environment, depletion experiment can be utilized. Clodronate liposomes are an effective and versatile way to deplete macrophages in vivo. Clodronate liposomes function on the principle of delivering a potent macrophage-depleting agent, clodronate, encapsulated within a lipid bilayer. When administered in vivo, these liposomes are specifically taken up by macrophages through a process known as phagocytosis. Once internalized, the liposomes release clodronate into the macrophage, ultimately resulting in cell death through apoptosis.

PBS liposomes do not contain clodronate, and liposomes contain only PBS, which can be used for control group experiments. This product requires use in conjunction with Clodronate Liposomes (Cat. No. K2721).

Figure 1: Mouse were treated with PBS Liposomes (Cat. Number: K2722) or Clodronate Liposomes (Cat. Number: K2721). Tissue was taken after death for the mouse macrophage maker F4/80 staining. The result showed that Clodronate Liposomes could significantly deplete macrophages