Orexin A (human, rat, mouse)
Catalog No.
B5117
Endogenous agonist at orexin receptors
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Orexin A (human, rat, mouse; CAS 205640-90-0) is a hypothalamic neuropeptide composed of 33 amino acids, functioning as an endogenous agonist at orexin-1 and orexin-2 receptors. Binding to these G-protein coupled receptors, orexin A regulates multiple physiological processes including appetite, arousal states, locomotion, hypothalamic-pituitary-adrenal axis activity, and pain perception thresholds. Preclinical studies have demonstrated that intravenous administration of orexin A (3–30 mg/kg) significantly increases paw withdrawal latency in thermal nociception assays, suggestive of analgesic potential. Hence, orexin A serves as a useful tool for investigating neuroendocrine control mechanisms and corresponding therapeutic targets.
| Physical Appearance | A crystalline solid |
| Storage | Desiccate at -20°C |
| M.Wt | 3565.14 |
| Cas No. | 205640-90-0 |
| Formula | C152H247N47O44S4 |
| Solubility | ≥50.4 mg/mL in DMSO; ≥12.4 mg/mL in EtOH with ultrasonic; ≥50.7 mg/mL in H2O |
| SDF | Download SDF |
| Canonical SMILES | CC[C@]([C@@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O) |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
