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Orexin A (human, rat, mouse)

Catalog No.
B5117
Endogenous agonist at orexin receptors
Grouped product items
SizePriceStock Qty
500ug
$315.00
In stock
1mg
$574.00
In stock
5mg
$2,310.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Orexin A (human, rat, mouse; CAS 205640-90-0) is a hypothalamic neuropeptide composed of 33 amino acids, functioning as an endogenous agonist at orexin-1 and orexin-2 receptors. Binding to these G-protein coupled receptors, orexin A regulates multiple physiological processes including appetite, arousal states, locomotion, hypothalamic-pituitary-adrenal axis activity, and pain perception thresholds. Preclinical studies have demonstrated that intravenous administration of orexin A (3–30 mg/kg) significantly increases paw withdrawal latency in thermal nociception assays, suggestive of analgesic potential. Hence, orexin A serves as a useful tool for investigating neuroendocrine control mechanisms and corresponding therapeutic targets.

Chemical Properties

Physical AppearanceA crystalline solid
StorageDesiccate at -20°C
M.Wt3565.14
Cas No.205640-90-0
FormulaC152H247N47O44S4
Solubility≥50.4 mg/mL in DMSO; ≥12.4 mg/mL in EtOH with ultrasonic; ≥50.7 mg/mL in H2O
SDFDownload SDF
Canonical SMILESCC[C@]([C@@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Orexin A (human, rat, mouse)