Onametostat
Catalog No.
A9936
A inhibitor of the protein arginine methyltransferase 5 (PRMT5)
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Onametostat (CAS 2086772-26-9) is a small-molecule inhibitor targeting protein arginine methyltransferase 5 (PRMT5). PRMT5 catalyzes symmetric dimethylation of arginine residues, a post-translational modification associated with cancer cell proliferation and survival pathways when aberrantly activated. By selectively inhibiting PRMT5 catalytic activity, Onametostat suppresses symmetric arginine dimethylation and interferes with tumor cell growth. This compound holds promise for investigating PRMT5-driven cancers and exploring therapeutic effects in oncology research.
| Storage | Store at -20°C for 3 years. |
| M.Wt | 483.37 |
| Cas No. | 2086772-26-9 |
| Formula | C22H23BrN6O2 |
| Solubility | ≥16.33 mg/mL in DMSO with ultrasonic; ≥4.1 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | (1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol |
| SDF | Download SDF |
| Canonical SMILES | BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
