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Onametostat

Catalog No.
A9936
A inhibitor of the protein arginine methyltransferase 5 (PRMT5)
Grouped product items
SizePriceStock Qty
1mg
$90.00
In stock
5mg
$261.00
In stock
10mg
$443.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Onametostat (CAS 2086772-26-9) is a small-molecule inhibitor targeting protein arginine methyltransferase 5 (PRMT5). PRMT5 catalyzes symmetric dimethylation of arginine residues, a post-translational modification associated with cancer cell proliferation and survival pathways when aberrantly activated. By selectively inhibiting PRMT5 catalytic activity, Onametostat suppresses symmetric arginine dimethylation and interferes with tumor cell growth. This compound holds promise for investigating PRMT5-driven cancers and exploring therapeutic effects in oncology research.

Chemical Properties

StorageStore at -20°C for 3 years.
M.Wt483.37
Cas No.2086772-26-9
FormulaC22H23BrN6O2
Solubility≥16.33 mg/mL in DMSO with ultrasonic; ≥4.1 mg/mL in EtOH with ultrasonic; insoluble in H2O
Chemical Name (1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
SDFDownload SDF
Canonical SMILESBrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Onametostat