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Oleyl Trifluoromethyl Ketone

Catalog No.
C5719
potent inhibitor of FAAH
Grouped product items
SizePriceStock Qty
10mg (solution)
$134.00
Ship with 5-10 days
50mg (solution)
$582.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor [1][2].

Fatty acid amide hydrolase (FAAH) is a member of the serine hydrolase family of enzymes. FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs) that hydrolyzes both oleamide and anandamide as well as several other fatty acid amides [2].

Oleyl Trifluoromethyl Ketone is an analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone. Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor in both human and rat. In transfected COS-7 cells, 10 μM oleyl trifluoromethyl ketone inhibited hydrolysis of oleamide by human and rat FAAH activities by 95.7% and 94.8%, respectively [2].

References:
[1].  Cravatt BF, Giang DK, Mayfield SP, et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 1996 Nov 7;384(6604):83-7.
[2].  Giang DK, Cravatt BF. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42.

Chemical Properties

Physical AppearanceA solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
M.Wt334.5
Cas No.177987-23-4
FormulaC19H33F3O
SynonymsHeptadecyl Trifluoromethyl Ketone,OTK
Solubility≤25mg/ml in DMSO;25mg/ml in dimethyl formamide
Chemical Name1,1,1-trifluoro-10Z-nonadecen-2-one
SDFDownload SDF
Canonical SMILESCCCCCCCC/C=C\CCCCCCCC(=O)C(F)(F)F
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Oleyl Trifluoromethyl Ketone