Olanzapine-d3

Olanzapine-d3 is the stable isotope-labeled counterpart of Olanzapine. Olanzapine is an atypical antipsychotic drug mainly used to treat schizophrenia and bipolar disorder. Olanzapine binds with high affinity to multiple neurotransmitter receptors, including serotonin receptors (such as 5-HT2A, 5-HT2C, 5-HT3, 5-HT6), dopamine receptors (D1-D4), muscarinic receptors (M1-M5), and adrenergic α1 receptors. In in vitro studies, Olanzapine shows binding affinities to these receptors in the nanomolar to low micromolar range. As its deuterated isotope-labeled compound, Olanzapine-d3 is widely used in biomedical research, especially in drug metabolism and pharmacokinetic studies, serving as an internal standard for liquid chromatography-mass spectrometry (LC-MS) analysis to improve detection sensitivity and accuracy. In cellular and animal models, the use of Olanzapine-d3 helps to further understand the metabolic pathways and pharmacological mechanisms of Olanzapine. The dose or concentration used in experiments typically depends on the experimental design and research objectives.