Okadaic acid sodium
Okadaic acid sodium (Okadaic acid sodium, CAS No.: 209266-80-8) is a polyether toxin derived from marine dinoflagellates. Its primary mechanism of action is the inhibition of serine/threonine protein phosphatases (PP), among which the inhibition of PP2A is the most prominent, with an IC50 in the nanomolar range. Its inhibitory effects on PP1, PP3, PP4, and PP5 fall within the low nanomolar to low micromolar range. By inhibiting these phosphatases, okadaic acid sodium can increase the phosphorylation levels of various proteins, thereby affecting biological processes such as cell cycle, differentiation, and apoptosis. In in vitro studies, okadaic acid sodium is commonly used to induce cell cycle arrest and apoptosis, with specific doses and concentrations depending on the experimental design and research objectives. In addition, in animal models, okadaic acid sodium is used to study its role as a tumor promoter, helping to elucidate the mechanisms of protein phosphorylation in tumor initiation and progression.
| Storage | -20°C, sealed storage, away from moisture |
| M.Wt | 826.98 |
| Cas No. | 209266-80-8 |
| Formula | C44H67NaO13 |
| Chemical Name | sodium (R)-2-hydroxy-3-((2S,5R,6R,8S)-5-hydroxy-8-((R,E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-((1S,3S)-1-hydroxy-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but |
| SDF | Download SDF |
| Canonical SMILES | O[C@H]1[C@@]2(O[C@]([C@@H](/C=C/[C@@H]3O[C@]4(CC3)O[C@@]5([C@@](CC4)(O[C@]([C@H](C[C@H](C)[C@]6(O[C@]7(CC[C@H]6C)CCCCO7)[H])O)(C(=C)[C@H]5O)[H])[H])[H])C)(CC(C)=C2)[H])O[C@H](C[C@@](C(O)=O)(C)O)CC1.[Na] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |