NPE-caged-proton
NPE-caged-proton (CAS 1186195-63-0) is a small molecule reagent designed to achieve precise, photo-induced acidification in biological environments. Upon photoactivation, this compound rapidly releases protons, lowering the local pH to as low as 2.0. Studies demonstrate that controlled acidification between pH 4.0 and 5.5 activates the fusion protein GP64, promoting binding of enveloped viruses to acidic phospholipid-containing liposomes and subsequently triggering membrane fusion events. In viral entry and membrane interaction assays, NPE-caged-proton facilitates exploration of molecular interactions under defined acidic conditions, making it a valuable research reagent for investigating virus-host interactions and membrane fusion mechanisms.
| Physical Appearance | Off White solid |
| Storage | Store at -20°C |
| M.Wt | 269.21 |
| Cas No. | 1186195-63-0 |
| Formula | C8H8NNaO6S |
| Solubility | <26.92mg/ml in H2O; <26.92mg/ml in DMSO |
| Chemical Name | sodium (R)-1-(2-nitrophenyl)ethyl sulfate |
| SDF | Download SDF |
| Canonical SMILES | [O-][N+](C1=CC=CC=C1[C@@H](C)OS([O-])(=O)=O)=O.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
