Nortriptyline

Nortriptyline (CAS No.: 72-69-5) is a tricyclic antidepressant mainly used to treat major depressive disorder. Its mechanism of action primarily involves inhibiting the reuptake of norepinephrine and 5-hydroxytryptamine (serotonin), thereby increasing the concentrations of these neurotransmitters in the synaptic cleft and producing antidepressant effects. In addition, Nortriptyline has affinity for multiple receptors, including muscarinic acetylcholine receptors, histamine receptors, and 5-hydroxytryptamine receptors; these actions may be related to its side effects. In in vitro studies, Nortriptyline shows low micromolar activity in inhibiting the norepinephrine transporter. In cellular and animal models, Nortriptyline is commonly used to study the pathological mechanisms of depression and for drug screening, and its experimental dose or concentration typically depends on the specific experimental design and research objectives. It should be noted that the use of Nortriptyline may be accompanied by certain side effects, such as dry mouth, drowsiness, and dizziness, and researchers should fully consider these factors when designing experiments.