NNK
NNK (CAS 64091-91-4) is a nitrosamine compound, functioning as a tobacco-specific carcinogen in mammalian tissues and exhibiting tumorigenic activity in pulmonary cells. Additionally, it promotes phosphorylation at certain serine and threonine residues within targeted proteins, which may modulate downstream signaling pathways.
In experimental studies, NNK enhances the survival and proliferation of human lung cancer cells, tested across established cell lines involved in lung carcinogenesis. It can also stimulate distinct molecular pathways associated with carcinogenic transformation and cellular signaling cascades.
In research applications, NNK is widely used for the induction and study of lung cancer in animal models, particularly for the construction of mouse models that recapitulate human lung tumorigenesis.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 207.23 |
| Cas No. | 64091-91-4 |
| Formula | C10H13N3O2 |
| Solubility | ≥32.1 mg/mL in DMSO; ≥28 mg/mL in EtOH; ≥27.5 mg/mL in H2O |
| Chemical Name | N-methyl-N-(4-oxo-4-(pyridin-3-yl)butyl)nitrous amide |
| SDF | Download SDF |
| Canonical SMILES | O=C(CCCN(C)N=O)C1=CC=CN=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |