NMDA (N-Methyl-D-aspartic acid)
NMDA is an agonist of NMDA-receptor [1].
NMDA is a glutamate-like excitatory substance and is a particularly potent excitant. NMDA binds to NMDA-receptor and interacts with it. This interaction causes a conformational change in the receptor or associated membrane molecules, which opened pores to allow extracellular sodium ions to flow down their electrochemical gradient and depolarise the cell. However, NMDA is proved to be a poor substrate for the uptake transporters, suggesting that the excitatory effect could not be an indirect consequence of glutamate uptake. Besides that, NMDA is found to increase intracellular calcium and release arachidonic acid, both of which generate oxygen radicals, subsequently inducing neuronal death [1, 2].
References:
[1] Watkins JC, Jane DE. The glutamate story. Br J Pharmacol. 2006 Jan;147 Suppl 1:S100-8.
[2] Lafon-Cazal M, Pietri S, Culcasi M, Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 1993 Aug 5;364(6437):535-7.
- 1. Chuankai Fang , Di He , Yafen Qian. "BMP4-GPX4 can improve the ferroptosis phenotype of retinal ganglion cells and enhance their differentiation ability after retinal stem cell transplantation in glaucoma …." Hum Mol Genet. 2025 Apr 6;34(8):673-683. PMID: 39877959
- 2. Bei Wen, He Zhu, et al. "NMDA Receptors Regulate Oxidative Damage in Keratinocytes during Complex Regional Pain Syndrome in HaCaT Cells and Male Rats." Antioxidants (Basel). 2024 Feb 18;13(2):244 PMID: 38397842
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 147.13 |
| Cas No. | 6384-92-5 |
| Formula | C5H9NO4 |
| Solubility | insoluble in EtOH; ≥39.07 mg/mL in H2O; ≥7.36 mg/mL in DMSO |
| Chemical Name | (2R)-2-(methylamino)butanedioic acid |
| SDF | Download SDF |
| Canonical SMILES | CN[C@H](CC(O)=O)C(O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | NMDA（N-Methyl-D-aspartic acid）is a specific agonist of NMDA receptor | |||||
| Targets | NMDA receptor | |||||
| IC50 | ||||||
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