NBQX disodium salt
NBQX disodium salt (CAS 479347-86-9) is a water-soluble, competitive antagonist belonging to the class of quinoxalinedione derivatives. It functions as an AMPA receptor antagonist in central nervous system (CNS) neurons and exhibits potent antagonistic activity at kainate receptors in other neural tissues. Additionally, it suppresses glutamate-induced excitotoxicity by selectively inhibiting fast excitatory synaptic transmission mediated by AMPA/kainate receptors.
In various in vitro and in vivo experimental contexts, NBQX disodium salt demonstrates neuroprotective effects with [key metric (IC50/EC50/other values)], tested against [neuronal cell lines/animal seizure models]. It can also reduce neuronal cell death and limit seizure activity induced by excessive glutamatergic stimulation or ischemic injury.
In neuroscientific research and pharmacological studies, NBQX disodium salt is widely used for the characterization of synaptic transmission involving AMPA and kainate receptors, as well as for investigating the pathophysiology of neurodegenerative disorders and epilepsy. Its highly selective antagonistic profile makes it a valuable tool for dissecting glutamatergic signaling pathways and for exploring potential therapeutic avenues against excitotoxic and seizure-related conditions.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 380.24 |
| Cas No. | 479347-86-9 |
| Formula | C12H6N4O6SNa2 |
| Synonyms | FG9202 disodium; 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide, disodium salt |
| Solubility | Soluble in H2O |
| Chemical Name | sodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-bis(olate) |
| SDF | Download SDF |
| Canonical SMILES | NS(c1cccc2c1c([N+]([O-])=O)cc(nc1[O-])c2nc1[O-])(=O)=O.[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
HIP-009 cells |
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Reaction Conditions |
1 h incubation |
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Applications |
NBQX inhibited both AMPA or kainic acid (KA) induced signals in a concentration-dependent manner, with IC50 values being 0.7 ± 0.1 and 0.7 ± 0.03 µM, respectively. The AMPA-evoked calcium rise was completely inhibited by NBQX, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX treatment. |
| Animal experiment:[2] | |
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Animal models |
Male Wistar rats intraperitoneally injected with pentylenetetrazole |
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Dosage form |
20 mg/kg Once daily by intraperitoneal injection for 3 days |
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Applications |
NBQX was sufficient to decrease pentylenetetrazole-induced seizures through increasing the latency to seizures, decrease the duration of seizure onset, and reduce the scores for the severity of seizures. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Fukushima K, Tabata Y, Imaizumi Y, et al. Characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. Journal of Biomolecular Screening, 2014, 19(8): 1174-1184. 2. Chen W, Li YS, Gao J, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One, 2016, 11(11): e0166672. |
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Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
