NB-360

NB-360 is a potent, brain-penetrating, orally bioavailable dual inhibitor (BACE1=5nM; BACE2=6nM in mice and humans).NB-360 displays an excellent pharmacological profile in transgenic amyloid precursor protein (APP) mice and strongly reduces amyloid β-amyloid and neuroinflammation.NB-360 completely blocks the process of Aβ deposition in the brains of APP transgenic mice. The process of Aβ deposition in the brain of APP transgenic mice.NB-360 has excellent selectivity over the related aspartyl proteases pepsin, histone D, and histone E. NB-360 has been shown to completely block the process of Aβ deposition in the brain of APP transgenic mice.