Naloxegol Oxalate

Naloxegol Oxalate (CAS No.: 1354744-91-4) is a synthetic small molecule and peripherally selective mu opioid receptor antagonist widely categorized as a gastrointestinal opioid pharmacology research tool for mechanistic studies in translational life science and drug discovery programs, with reported receptor binding activity in the nanomolar range across sources and a functional profile consistent with inhibition of opioid ligand engagement at peripheral mu opioid receptors in the enteric system, thereby supporting investigation of opioid mediated suppression of gut motility, altered intestinal secretion and transport, and related receptor dependent signaling events in peripheral tissues while minimizing central pathway interrogation; in biomedical research workflows, it is commonly applied in receptor binding and functional antagonism assays, pathway deconvolution studies involving opioid receptor linked G protein signaling, and preclinical efficacy characterization in cell based and animal models designed to examine opioid associated gastrointestinal dysfunction, and it is also used as a comparator compound in screening cascades for next generation peripherally restricted opioid receptor modulators, with experimental concentrations in vitro generally selected within nanomolar to micromolar ranges and in vivo doses adjusted according to model type, route, pharmacokinetic behavior, and study endpoints, as concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.