N1-Methyl-2'-O-Methylpseudo-UTP
Catalog No.
B8070
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N1-Methyl-2'-O-Methylpseudo-UTP is a chemically modified uridine triphosphate analog, incorporating an N1-methylpseudouridine base and a 2'-O-methyl ribose modification. Structurally designed to substitute natural UTP during in vitro RNA synthesis, this compound is efficiently incorporated into RNA transcripts by T7 RNA polymerase. RNAs synthesized using this modified nucleotide exhibit reduced immunogenic responses, facilitating investigations into RNA structure-function relationships, innate immune sensing mechanisms, and the development of messenger RNA therapeutics.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 512.1 (free acid) |
| Formula | C11H19N2O15P3 (free acid) |
| Synonyms | N1-Methyl-2'-O-Methylpseudouridine-5'-Triphosphate, N1,2'-O-Dimethylpseudo-UTP |
| Chemical Name | lithium (3-hydroxy-4-methoxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C(N(C)C=C1C2C(OC)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |