ML329
ML329 (CAS No.: 19992-50-8) is a small-molecule inhibitor of the microphthalmia-associated transcription factor (MITF) signaling pathway, a key regulator of melanocyte development, differentiation, and melanoma cell survival. It suppresses transcriptional activity of MITF by inhibiting the promoter activity of its downstream target gene TRPM-1, exhibiting inhibitory potency in the low micromolar range. Functionally, ML329 demonstrates selective cytotoxicity toward MITF-dependent melanoma cell lines, such as SK-MEL-5 and MALME-3M, while showing substantially reduced activity in MITF-independent models, highlighting its utility for dissecting MITF-driven oncogenic programs. As a pathway-focused probe, ML329 is widely used in studies of melanoma biology, transcriptional regulation, and lineage-specific vulnerabilities, and serves as a valuable tool in target validation and phenotypic screening campaigns aimed at identifying novel therapeutics that modulate MITF signaling. Experimental concentrations typically vary depending on assay design, cell type, and intended mechanistic endpoints.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 328.34 |
| Cas No. | 19992-50-8 |
| Formula | C16H12N2O4S |
| Solubility | ≥11.9 mg/mL in DMSO |
| Chemical Name | 4-((1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide |
| Canonical SMILES | O=S(C1=CC=C(NC(C2=O)=CC(C3=C2C=CC=C3)=O)C=C1)(N)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
