ML-264
Catalog No.
C3474
Krüppel-like factor 5 (KLF5) inhibitor
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ML-264 (CAS 1550008-55-3) is a selective small molecule inhibitor targeting Krüppel-like factor 5 (KLF5), a transcription factor that facilitates proliferation in intestinal epithelial cells and is implicated in colorectal cancer progression. Mechanistically, ML-264 suppresses KLF5 expression and disrupts downstream MAPK signaling by reducing EGR1 levels, a transcriptional activator of KLF5. In cell-based assays, ML-264 shows potent antiproliferative activity against colorectal cancer lines (DLD-1 IC50: 29 nM; HT29 and SW620 IC50: 130 nM), sparing non-cancerous IEC-6 cells. In vivo, ML-264 inhibits tumor growth in colorectal cancer xenograft models, highlighting its relevance as a research tool in cancer biology.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 384.9 |
Cas No. | 1550008-55-3 |
Formula | C17H21ClN2O4S |
Solubility | ≥48.6 mg/mL in DMSO; ≥2.34 mg/mL in EtOH with gentle warming and ultrasonic; insoluble in H2O |
Chemical Name | (2E)-3-(3-chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-2-propenamide |
SDF | Download SDF |
Canonical SMILES | ClC1=CC=CC(/C=C/C(NCC(N(C)C2CCS(CC2)(=O)=O)=O)=O)=C1 |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
