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MJ33 (lithium salt)

Catalog No.
C5346
inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6
Grouped product items
SizePriceStock Qty
5mg
$242.00
Ship with 5-10 days
10mg
$428.00
Ship with 5-10 days
25mg
$939.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

MJ33 (lithium salt; CAS: 1007476-63-2, 199106-13-3) is a small molecule inhibitor of the acidic, calcium-independent phospholipase A2 (aiPLA2) activity of peroxiredoxin-6 (Prdx6). Prdx6 exhibits dual enzymatic functions, encompassing both glutathione peroxidase and PLA2 activities. It plays a role in lung surfactant lipid metabolism, particularly processing dipalmitoylphosphatidylcholine. MJ33 selectively suppresses aiPLA2 activity, as demonstrated through inhibition of phosphorylation-stimulated recombinant and native Prdx6 in vitro. Moreover, MJ33 has shown protective effects in animal models, attenuating ROS generation, inflammatory cytokine release, NF-κB activation, and tissue damage in LPS-induced acute lung injury, highlighting its utility for inflammation-related biomedical research.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt498.5
Cas No.1007476-63-2;199106-13-3
FormulaC22H43F3O6P·Li
Solubility≤2mg/ml in ethanol;0.25mg/ml in DMSO;0.5mg/ml in dimethyl formamide
Chemical Namemono[1-​[(hexadecyloxy)​methyl]​-​2-​(2,​2,​2-​trifluoroethoxy)​ethyl] monomethyl ester phosphoric acid, monolithium salt
SDFDownload SDF
Canonical SMILESO=P(OC)([O-])OC(COCC(F)(F)F)COCCCCCCCCCCCCCCCC.[Li+]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

MJ33 (lithium salt)

Related Biological Data

MJ33 (lithium salt)

Related Biological Data

MJ33 (lithium salt)