MJ33 (lithium salt)

MJ33 (lithium salt; CAS: 1007476-63-2, 199106-13-3) is a small molecule inhibitor of the acidic, calcium-independent phospholipase A2 (aiPLA2) activity of peroxiredoxin-6 (Prdx6). Prdx6 exhibits dual enzymatic functions, encompassing both glutathione peroxidase and PLA2 activities. It plays a role in lung surfactant lipid metabolism, particularly processing dipalmitoylphosphatidylcholine. MJ33 selectively suppresses aiPLA2 activity, as demonstrated through inhibition of phosphorylation-stimulated recombinant and native Prdx6 in vitro. Moreover, MJ33 has shown protective effects in animal models, attenuating ROS generation, inflammatory cytokine release, NF-κB activation, and tissue damage in LPS-induced acute lung injury, highlighting its utility for inflammation-related biomedical research.