MJ33 (lithium salt)
MJ33 (lithium salt; CAS: 1007476-63-2, 199106-13-3) is a small molecule inhibitor of the acidic, calcium-independent phospholipase A2 (aiPLA2) activity of peroxiredoxin-6 (Prdx6). Prdx6 exhibits dual enzymatic functions, encompassing both glutathione peroxidase and PLA2 activities. It plays a role in lung surfactant lipid metabolism, particularly processing dipalmitoylphosphatidylcholine. MJ33 selectively suppresses aiPLA2 activity, as demonstrated through inhibition of phosphorylation-stimulated recombinant and native Prdx6 in vitro. Moreover, MJ33 has shown protective effects in animal models, attenuating ROS generation, inflammatory cytokine release, NF-κB activation, and tissue damage in LPS-induced acute lung injury, highlighting its utility for inflammation-related biomedical research.
- 1. Huiqing Wang, Yao Zhou, et al. "Ferrostatin-1 attenuates brain injury in animal model of subarachnoid hemorrhage via phospholipase A2 activity of PRDX6." Neuroreport. 2023 Aug 2;34(12):606-616. PMID: 37395228
- 2. Wen-ying Yang, Xiang Meng, et al. "PRDX6 Alleviates Lipopolysaccharide-induced Inflammation in Human Gingival Fibroblasts by Regulation of NRF2." Research Square. rs-1108989/v1.
- 3. Lu B, Chen XB, et al. "Identification of PRDX6 as a regulator of ferroptosis." Acta Pharmacol Sin. 2019 Apr 29. PMID:31036877
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 498.5 |
Cas No. | 1007476-63-2;199106-13-3 |
Formula | C22H43F3O6P·Li |
Solubility | ≤2mg/ml in ethanol;0.25mg/ml in DMSO;0.5mg/ml in dimethyl formamide |
Chemical Name | mono[1-[(hexadecyloxy)methyl]-2-(2,2,2-trifluoroethoxy)ethyl] monomethyl ester phosphoric acid, monolithium salt |
SDF | Download SDF |
Canonical SMILES | O=P(OC)([O-])OC(COCC(F)(F)F)COCCCCCCCCCCCCCCCC.[Li+] |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity ≥ 95.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure

Related Biological Data

Related Biological Data
