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Mitraphylline

Catalog No.
A9072
Major pentacyclic oxindole alkaloid found in Uncaria tomentosa, inhibits lipopolysaccharide-induced activation of primary human neutrophils.
Grouped product items
SizePriceStock Qty
5mg
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10mg
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For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Mitraphylline is the major pentacyclic oxindole alkaloid found in Uncaria tomentosa and exhibits both anti-inflammatory and antiproliferative properties. It reduces production of nitric oxide (NO), IL-8, IL-6, and TNF-a as well as expression of inducible nitric oxide synthase (iNOS) in LPS-activated human neutrophils.

Chemical Properties

StorageStore at 4°C away from moisture and light
M.Wt368.43
Cas No.509-80-8
FormulaC21H24N2O4
Solubility≥9.13 mg/mL in DMSO; ≥2.83 mg/mL in EtOH with gentle warming and ultrasonic; insoluble in H2O
Chemical Namemethyl (1'S,3R,4a'S,5a'S,10a'R)-1'-methyl-2-oxo-4a',5',5a',7',8',10a'-hexahydro-1'H,10'H-spiro[indoline-3,6'-pyrano[3,4-f]indolizine]-4'-carboxylate
SDFDownload SDF
Canonical SMILESO=C(OC)C1=CO[C@@H](C)[C@]2([H])[C@]1([H])C[C@]([C@]3(C(C=CC=C4)=C4NC3=O)CC5)([H])N5C2
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Mitraphylline