Minaprine dihydrochloride

Minaprine dihydrochloride (CAS No.: 25905-77-5) is a synthetic small molecule neuropharmacology research reagent and the dihydrochloride salt form of minaprine, primarily categorized as a monoamine oxidase modulator for central nervous system pathway investigation, with reported blood brain barrier permeability in preclinical settings and a functional profile characterized by reversible inhibition of monoamine oxidase A together with weak acetylcholinesterase inhibition in brain homogenate based assays, supporting its use as a tool compound for studying monoaminergic and cholinergic network crosstalk, neurotransmitter turnover, and enzyme regulated signaling dynamics; mechanistic studies indicate reduced intraneuronal dopamine catabolism and altered striatal metabolite patterns, including decreases in homovanillic acid and dihydroxyphenylacetic acid with increases in 3 methoxytyramine and serotonin related tone, consistent with modulation of dopamine and serotonin pathway homeostasis, while available biochemical and pharmacology literature generally supports activity in the low micromolar to micromolar range for enzyme associated effects depending on assay matrix and species context, and in vitro and in vivo applications commonly include neuronal cell systems, ex vivo brain tissue preparations, and rodent neurochemistry or behavior paradigms for mechanism elucidation and comparative screening against other monoamine oxidase active scaffolds, where the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.