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MI-nc (hydrochloride)

Catalog No.
C3379
weak inhibitor of menin-MLL interaction
Grouped product items
SizePriceStock Qty
1mg
$91.00
Ship with 5-10 days
5mg
$318.00
Ship with 5-10 days
10mg
$589.00
Ship with 5-10 days
25mg
$1,358.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

MI-nc is a weak inhibitor of the menin-MLL fusion protein interaction with an IC50 of 193 μM. It can be used as a negative control compound for tests involving MI-2, which showed more binding potency with menin, blocked the menin-MLL interaction with an IC50 of 0.45 μM, and induced apoptosis in cells expressing MLL fusion proteins [1].

Menin, a product of the multiple endocrine neoplasia gene, is an essential co-factor of oncogenic MLL fusion proteins. MLL interacts with menin in a bivalent mode involving 2 N-terminal fragments of MLL, and the menin–MLL interaction is critical for development of acute leukemia. Inhibition of the menin interaction with MLL fusion proteins is a very promising strategy to reverse their oncogenic activity [2].

References:
[1].  Grembecka J, He S, Shi A, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia[J]. Nature chemical biology, 2012, 8(3): 277-284.
[2].  Yokoyama A, Somervaille T C P, Smith K S, et al. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis[J]. Cell, 2005, 123(2): 207-218.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt405.4
Cas No.1934302-23-4
FormulaC14H16N6S2·2HCl
Solubility≤0.1mg/ml in ethanol;1.3mg/ml in DMSO;0.5mg/ml in dimethyl formamide
Chemical Name6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]-thieno[2,3-d]pyrimidine, dihydrochloride​
SDFDownload SDF
Canonical SMILESCCC(S1)=CC(C1=NC=N2)=C2N3CCN(C4=NN=CS4)CC3.Cl.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

MI-nc (hydrochloride)