MI-2-2
Catalog No.
BA4701
MI-2-2 is a potent inhibitor.
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MI-2-2 is a potent inhibitor.MI-2-2 binds to menin with low nanomolar affinity (=22nM) and very efficiently disrupts bivalent protein-protein interactions between menin and MLL.MI-2-2 has specific and highly significant activities in MLL leukemia cells, including inhibition of cell proliferation, downregulation of Hoxa9 expression and differentiation .
| Physical Appearance | A solid |
| Storage | Tightly sealed and desiccated at -20°C, protect from light |
| M.Wt | 415.50 |
| Cas No. | 1454920-20-7 |
| Formula | C17H20F3N5S2 |
| Solubility | ≥22.65 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine |
| Canonical SMILES | FC(F)(F)CC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
