Mertansine
Catalog No.
BA2321
Mertansine (DM1) is an inhibitor and an antibody-conjugatable medetomidine alkaloid used to overcome the systemic toxicity associated with medetomidine and to enhance tumor-specific delivery.
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Mertansine (DM1) is an inhibitor and an antibody-conjugatable medetomidine alkaloid used to overcome the systemic toxicity associated with medetomidine and to enhance tumor-specific delivery.Mertansine can be attached to monoclonal antibodies via a linker to form antibody-coupled active molecules (ADCs).
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 738.29 |
| Cas No. | 139504-50-0 |
| Formula | C35H48ClN3O10S |
| Synonyms | DM1;Maytansinoid DM1 |
| Solubility | ≥26.65 mg/mL in DMSO; ≥4.36 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(3-mercaptopropanoyl)-N-methyl-L-alaninate |
| SDF | Download SDF |
| Canonical SMILES | ClC1=C(N(C)C2=O)C=C(C/C(C)=C/C=C/[C@](OC)([H])[C@@]3(O)C[C@@](OC(N3)=O)([H])[C@@H](C)[C@H](O4)[C@]4(C)[C@](OC([C@H](C)N(C(CCS)=O)C)=O)([H])C2)C=C1OC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |