Melatonin-d4

Melatonin-d4 is the stable isotope-labeled analog of Melatonin. Melatonin is a hormone secreted by the pineal gland and mainly participates in regulating physiological processes such as circadian rhythms, the sleep–wake cycle, blood pressure regulation, and seasonal reproduction by activating melatonin receptors (melatonin receptor). In addition, Melatonin has antioxidant and anti-inflammatory properties. In biomedical research, Melatonin-d4, as an isotope-labeled tracer of endogenous Melatonin, is widely used in pharmacokinetic and metabolism studies. Leveraging its isotopic properties, techniques such as mass spectrometry analysis are used to accurately track and quantify the metabolic pathways and rates of endogenous Melatonin. In cell and animal models, Melatonin-d4 can be used to study Melatonin absorption, distribution, metabolism, and excretion (ADME) processes, helping to elucidate its dynamic changes in vivo. The dose or concentration used in experiments typically depends on the experimental design and research objectives. Through these studies, scientists can gain a deeper understanding of the biological functions of Melatonin, providing a scientific basis for its applications in areas such as sleep disorders, antioxidation, and anti-inflammation.