Mechlorethamine HCl
Catalog No.
B1785
DNA synthesis inhibitor
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Mechlorethamine HCl (55-86-7) is a bifunctional nitrogen mustard derivative with DNA alkylating activity. It forms covalent bonds with guanine residues, resulting in cross-linkages between DNA strands and thereby disrupting DNA replication and transcription. This leads to inhibition of cellular proliferation. Mechlorethamine HCl is employed in research to investigate DNA damage and repair pathways, analyze tumor-cell susceptibility to DNA-targeting agents, and assess cellular responses such as apoptosis and cell survival. It also serves as a model in studies of alkylating chemotherapeutic drug action and toxicity.
- 1. Monika Witzenberger, Sandra Burczyk, et al. "Human TRMT2A methylates tRNA and contributes to translation fidelity." Nucleic Acids Res. 2023 Sep 8;51(16):8691-8710. PMID: 37395448
- 2. Witzenberger, Monika. "Multi-layered characterization of the tRNA methyltransferase TRMT2A and its therapeutic potential for polyQ diseases." University of Ulm. 2021.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 192.51 |
| Cas No. | 55-86-7 |
| Formula | C5H11Cl2N·HCl |
| Solubility | ≥47.5 mg/mL in EtOH; ≥57.3 mg/mL in H2O; ≥9.65 mg/mL in DMSO |
| Chemical Name | 2-chloro-N-(2-chloroethyl)-N-methylethanamine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CN(CCCl)CCCl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
