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MCC950 sodium

Catalog No.
B7946
Potent NLRP3 inflammasome inhibitor
Grouped product items
SizePriceStock Qty
10mg
$75.00
In stock
50mg
$313.00
In stock
200mg
$698.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

MCC950 sodium (CAS 256373-96-3) is a selective small-molecule inhibitor targeting the NOD-like receptor family protein 3 (NLRP3) inflammasome. MCC950 sodium inhibits NLRP3 activation in murine bone marrow-derived macrophages (BMDMs) with an IC50 of 7.5 nM and demonstrates comparable selectivity and potency in human monocyte-derived macrophages (HMDMs). It specifically blocks both canonical and noncanonical activation pathways without affecting other inflammasomes such as AIM2, NLRC4, and NLRP1. Due to its selectivity, MCC950 sodium is valuable in investigating NLRP3-associated inflammatory and autoimmune conditions.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt426.46
Cas No.256373-96-3
FormulaC20H23N2NaO5S
SynonymsCRID3 sodium salt
Solubility≥124 mg/mL in H2O; ≥21.45 mg/mL in DMSO; ≥43 mg/mL in EtOH
Chemical Namesodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide
SDFDownload SDF
Canonical SMILESO=S([N-]C(NC1=C2CCCC2=CC3=C1CCC3)=O)(C4=CC(C(O)(C)C)=CO4)=O.[Na+]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Bone marrow derived macrophages (BMDMs), human monocyte–derived macrophages (HMDMs), and human peripheral blood mononuclear cells (PBMCs)

Reaction Conditions

0.001 ~ 10 μM MCC950 sodium for 30 min incubation

Applications

Treating cells with nanomolar concentrations of MCC950 sodium dose-dependently inhibited the release of interleukin-1β (IL-1β) in BMDMs, HMDMs, and PBMCs. LPS-dependent tumor necrosis factor-α (TNF-α) secretion was not impaired by MCC950 sodium, which demonstrated that the inhibition effect of MCC950 sodium on IL-1β secretion was specific.

Animal experiment:[1]

Animal models

C57BL/6 mice

Dosage form

10 and 50 mg/kg

Injected intraperitoneally (i.p.)

Applications

In mice intraperitoneally injected with lipopolysaccharides (LPS), pre-treatment with MCC950 sodium (50 mg/kg, i.p., 1 h before LPS injection) reduced serum concentrations of IL-1β and IL-6 while it did not considerably decrease the amount of TNF-α. Furthermore, MCC950 sodium (10 mg/kg, i.p.) attenuated the severity of experimental autoimmune encephalomyelitis, a disease model of multiple sclerosis.

Note

The technical data provided above is for reference only.

References:

1. Coll RC, Robertson AA, Chae JJ. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 2015, 21(3): 248-255.

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