m-Iodobenzylguanidine (hemisulfate)

m-Iodobenzylguanidine (hemisulfate) (CAS No.: 87862-25-7) is a synthetic analog of norepinephrine, mainly used for studying antitumor properties in biomedical research. As a high-affinity substrate of cholera toxin, this compound affects multiple signaling pathways by interfering with intracellular mono(ADP-ribosyl)ation processes. After radiolabeling with radioactive iodine, m-iodobenzylguanidine is used in tumor-targeted radiopharmaceuticals, assisting in the diagnosis of adrenergic tumors through imaging techniques. Its accumulation in chromaffin tissues and adrenergic tumors increases its value for applications in the study of neuroendocrine malignancies. In vitro studies show that m-iodobenzylguanidine inhibits the cell growth of various human and murine cancer cell lines at low micromolar levels, including leukemia, fibrosarcoma, melanoma, and neuroblastoma. In animal models, particularly in mouse xenograft models, this compound has shown an effect of increasing survival rates at experimentally determined doses. Due to its characteristics as a norepinephrine analog and its selective tumor accumulation, m-iodobenzylguanidine plays a valuable role in drug screening and cancer research, and the concentrations used in experiments are usually adjusted according to the specific experimental design and research objectives.