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LY2835219 free base CDK inhibitor

Catalog No.A3575
Size Price Stock Qty
5mg
$80.00
In stock
25mg
$180.00
In stock
100mg
$450.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

LY2835219 free base

LY2835219 free base Dilution Calculator

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Chemical Properties

Cas No. 1231929-97-7 SDF Download SDF
Synonyms CDK4/6 dual inhibitor;LY 2835219 (free base);LY-2835219 (free base)
Chemical Name N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
Canonical SMILES CCN1CCN(CC2=CN=C(NC3=NC=C(F)C(C4=CC5=C(N=C(C)N5C(C)C)C(F)=C4)=N3)C=C2)CC1
Formula C27H32F2N8 M.Wt 506.59
Solubility DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 dual inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.