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Luotonin F

Catalog No.
C4228
stabilizing the DNA topoisomerase I-DNA complex
Grouped product items
SizePriceStock Qty
5mg
$259.00
Ship with 5-10 days
10mg
$452.00
Ship with 5-10 days
25mg
$1,051.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Luotonin F is an alkaloid found in the aerial parts of the Peganum nigellastrum Bunge, a plant which has been long used in traditional Chinese medicine for the treatment of rheumatism, abscesses, and various other inflammatory conditions [1].

Due to their biological and pharmaceutical activities, many synthetic methods have been developed for the synthesis of luotonins. An efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin F from easily available starting materials. Through the rational logical design, multifundamental reactions were assembled in one-pot, such as iodination, Kornblum oxidation, and annulations [2]. The developed approach could efficiently synthesize luntonin F and various analogues. Luotonin F showed promising cytotoxicity against leukemia P-388 cells with an IC50 value of 2.3 μg/ml by stabilizing the DNA topoisomerase I-DNA complex [1].

References:
[1] Liang J L, Cha H C, Jahng Y.  Recent advances in the studies on luotonins[J]. Molecules, 2011, 16(6): 4861-4883.
[2] Zhu Y, Fei Z, Liu M, et al.  Direct one-pot synthesis of Luotonin F and analogues via rational logical design[J]. Organic letters, 2012, 15(2): 378-381.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt301.3
Cas No.244616-85-1
FormulaC18H11N3O2
Solubility≤2.5mg/ml in DMSO;2.5mg/ml in dimethyl formamide
Chemical Name2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone
SDFDownload SDF
Canonical SMILESO=C1NC(C(C2=CC(C=CC=C3)=C3N=C2)=O)=NC4=CC=CC=C41
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Luotonin F