Liraglutide
Liraglutide (CAS 204656-20-2) is a peptide-based agonist targeting the glucagon-like peptide-1 receptor (GLP-1R), a G protein-coupled receptor predominantly expressed in pancreatic β cells and vascular endothelial cells. Activation of GLP-1R facilitates glucose-dependent insulin secretion and maintains glucose homeostasis. In endothelial cell studies (C11-STH^20), liraglutide (100 nM) reduced expression of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecules, mitigating endothelial dysfunction. In ApoE^-/- mice, liraglutide administration (300 μg/kg, twice daily, subcutaneously) increased endothelial nitric oxide synthase (eNOS) and decreased intercellular adhesion molecule-1 (ICAM-1) expression, effects mediated specifically through GLP-1R signaling. These properties make liraglutide valuable for research on endothelial function and vascular complications in diabetic contexts.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 3751.20 |
| Cas No. | 204656-20-2 |
| Formula | C172H265N43O51 |
| Solubility | insoluble in EtOH; insoluble in DMSO; insoluble in H2O |
| SDF | Download SDF |
| Canonical SMILES | CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC( |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
