LDN193189 2HCl
LDN193189 2HCl (CAS No.: 1435934-00-1) is the dihydrochloride form of LDN193189 (CAS No.: 1062368-24-4, Cat. No.: A8324). LDN193189 is a selective inhibitor of transcriptionally active bone morphogenetic protein (BMP) type I receptors, inhibiting activin receptor-like kinase-2 (ALK2) and ALK3, with IC50 values of 5 nM and 30 nM, respectively[1].
In C2C12 cells, LDN193189 inhibits BMP-induced phosphorylation of Smad signaling (Smad1/5/8) and non-Smad signaling, including p38 and Akt[2].
In bronchial epithelial (Beas2B) cells and C57BL/6 mice, pharmacological inhibition of BMP by LDN193189 prevents BMP2-induced downregulation of E-cadherin. LDN193189 also inhibits BMP-induced reduction of epithelial permeability at the cellular level[3].
References:
[1] Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec;14(12):1363-9.
[2] Boergermann JH1, Kopf J, Yu PB, Knaus P. Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Int J Biochem Cell Biol. 2010 Nov;42(11):1802-7.
[3] Helbing T1, Herold EM, Hornstein A, Wintrich S, Heinke J, Grundmann S, Patterson C, Bode C, Moser M. Inhibition of BMP activity protects epithelial barrier function in lung injury. J Pathol. 2013 Sep;231(1):105-16. doi: 10.1002/path.4215. Epub 2013 Jul 10.
| Storage | Store at -20°C |
| M.Wt | 479.40 |
| Cas No. | 1435934-00-1 |
| Formula | C25H22N6· 2HCl |
| Synonyms | LDN193189 dihydrochloride, DM-3189 dihydrochloride |
| Chemical Name | 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline dihydrochloride |
| Canonical SMILES | C12=CC=CC=C1N=CC=C2C3=C4N(C=C(C5=CC=C(N6CCNCC6)C=C5)C=N4)N=C3.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |