Lamotrigine-13c,d3

Lamotrigine-13c,d3 (CAS No.: 2517756-06-6) is the stable isotope-labeled counterpart of lamotrigine (Lamotrigine). Lamotrigine is an effective oral anticonvulsant or antiepileptic agent that selectively blocks voltage-gated sodium channels, stabilizes presynaptic neuronal membranes, and inhibits glutamate release. In in vitro studies, lamotrigine blocks sustained repetitive neuronal firing in a dose-dependent manner and effectively inhibits the release of glutamate and aspartate, but has no significant effect on the release of acetylcholine and γ-aminobutyric acid. Lamotrigine is mainly inactivated via hepatic microsomal glucuronidation metabolism; its mechanism of action is similar to that of phenytoin and carbamazepine, producing a slight frequency-dependent inhibition of depolarizing potentials by modulating fast voltage-dependent sodium currents. The isotope-labeling properties of Lamotrigine-13c,d3 make it important for applications in drug metabolism and pharmacokinetic studies, helping to track and quantify lamotrigine’s metabolic pathways and distribution in in vivo and in vitro experiments, thereby enabling a deeper understanding of its pharmacological effects and metabolic processes.