L-Canaline

L-Canaline (CAS 496-93-5) is a naturally occurring aminooxy derivative known to irreversibly inhibit pyridoxal phosphate-dependent enzymes, particularly ornithine aminotransferase (OAT). Its mechanism involves covalent binding via oxime formation with pyridoxal 5′-phosphate, the essential coenzyme of OAT. L-Canaline demonstrates potent inhibitory activity toward OAT, with a reported IC50 of approximately 3 × 10?? M. This compound has been utilized in biochemical research to elucidate enzyme functions in amino acid metabolism and to study metabolic pathways involving pyridoxal-dependent enzymes.