L-Alanyl-L-Glutamine

L-Alanyl-L-glutamine is a stable, water-soluble dipeptide comprised of L-glutamine and L-alanine. L-Alanyl-L-glutamine is used as a nutritional supplement with potential protective and absorption enhancing activities. After oral or enteral administration, L-alanyl-L-glutamine works locally in the gastrointestinal tract, protecting the integrity of the intestinal mucosa and maintaining intestinal barrier functions. This reduces bacterial translocation, infection risk, as well as infection-associated symptoms including diarrhea, malabsorption, dehydration, as well as electrolyte imbalances. L-Alanyl-L-glutamine also increases absorption of other chemicals such as L-glutamine. In addition, L-alanyl-L-glutamine has been shown to benefit the antioxidant system, attenuate inflammation, and modulate the heat shock protein response in catabolic situations. 

References:

1. National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 123935, l-Alanyl-l-glutamine. Retrieved September 6, 2021.

2. Harris RC, Hoffman JR, Allsopp A, et al. L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein. Nutrition Research, 2012, 32(4): 272-277.

3. Cruzat VF, Keane KN, Scheinpflug AL, et al. Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge. Journal of Endocrinology, 2015, 224(3): 261-271.