L(+)-2-Aminobutyric acid

L(+)-2-Aminobutyric acid (CAS No.: 1492-24-6) is a non-proteinogenic amino acid present in human tissues and biofluids that participates in multiple amino acid metabolic pathways and arises from the transamination of oxobutyric acid. It is recognized as a metabolically relevant intermediate and biomarker candidate, with plasma level alterations associated with inborn errors of metabolism and related disorders, supporting its use in studies of metabolic compensation mechanisms and disease pathophysiology. Functionally, L(+)-2-aminobutyric acid has been reported to modulate immune responses, including inhibition of lipopolysaccharide-induced nitric oxide production and attenuation of bactericidal activity in macrophages, indicating involvement in inflammatory signaling pathways and innate immune regulation. In experimental systems, activity is typically observed in the micromolar to millimolar concentration range, consistent with its role as an endogenous metabolite influencing cellular metabolism and redox balance. In vivo, it has demonstrated protective effects in models of systemic inflammation and intestinal injury, supporting its relevance in immunometabolism and disease modeling. Additionally, it serves as a key synthetic intermediate and precursor in the development of pharmaceutical agents, including anticonvulsant and antimycobacterial compounds, making it valuable for medicinal chemistry and drug discovery applications. It is commonly employed in cell-based assays, metabolic profiling, and animal studies, where dosing and concentrations are adjusted according to specific experimental objectives.