KU-60019

KU-60019 (CAS No.: 925701-46-8) is a highly selective small-molecule inhibitor of ataxia telangiectasia mutated (ATM) kinase, a central regulator of the DNA damage response pathway that orchestrates cell cycle checkpoint control, DNA repair, and cellular survival through phosphorylation of multiple downstream substrates. By potently inhibiting ATM kinase activity, KU-60019 attenuates ATM-dependent signaling cascades triggered by DNA double-strand breaks, thereby modulating checkpoint activation and impairing efficient DNA repair processes. It exhibits strong in vitro activity in the low nanomolar range, reflecting high affinity and specificity toward ATM relative to related kinases. This compound is widely employed as a research tool in molecular and cellular biology to investigate mechanisms of genome stability, DNA damage signaling networks, and checkpoint regulation, as well as to explore cellular responses to genotoxic stress in cancer and other disease-relevant models. In experimental settings, KU-60019 is frequently utilized in cell-based assays and preclinical model systems to study pathway inhibition and to evaluate combinatorial effects with DNA-damaging agents or irradiation, with concentrations or dosing regimens adjusted according to specific experimental designs and objectives.