Khellin

Khellin (CAS No.: 82-02-0) is a natural furochromone derived from Ammi visnaga L., primarily recognized as an epidermal growth factor receptor (EGFR) inhibitor, exhibiting in vitro antiproliferative properties at low micromolar levels. As a vasodilator, its molecular activity extends to bronchodilatory effects, making it significant in studies of smooth muscle relaxation. The antispasmodic properties and coronary vasodilatory effects of Khellin further underscore its application value in cardiovascular research. Its mechanism of action is particularly noteworthy, as it can inhibit specific signaling pathways associated with cell proliferation and vascular regulation. In cellular and animal models, Khellin is widely used in experimental research and drug screening, with application concentrations or doses typically determined according to the specific needs of the study. Due to its diverse biological activities, Khellin has become an important tool in the field of drug discovery, supporting research into potential pharmacological pathways without involving human consumption or therapeutic applications.