Toggle Nav
Close
  • Menu
  • Setting

K145

Catalog No.
B1298
SphK2 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$109.00
Ship with 10-15 days
10mg
$182.00
Ship with 10-15 days
50mg
$654.00
Ship with 10-15 days
100mg
$1,174.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

K145 is a selective inhibitor of Sphingosine Kinase-2 (SphK2) with IC50 value of 4.3μM [1].

K145 is an analogue of sphingosine. It competes with the substrate of SphK2 and shows Ki value of 6.4μM in the in vitro assay. K145 is selective against SphK2 over SphK1 and CERK. In U937 cells, K145 decreases total cellular S1P and inhibits the phosphorylation of FTY720 (Both S1P and FTY720 are substrates of SphK2). Meanwhile, K145 suppresses cell growth and induces late apoptosis significantly. It is also found to inhibit the phosphorylation of ERK and Akt in this cell line [1].

In the U937 xenograft model in mice, K145 inhibits tumor growth with a TGI value of 44.2% and has less toxicity than tamibarotene. In BALB/c mice bearing the JC xenograft, K145 also shows potent inhibitory effects on tumor growth. Moreover, in BALB/c-nu mice bearing U937 xenograft, oral administration of K145 exerts better antitumor activity than tamibarotene [1].

References:
[1] Liu K, Guo T L, Hait N C, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2, 4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PloS one, 2013, 8(2): e56471.

Chemical Properties

StorageStore at -20°C
M.Wt348.46
Cas No.1309444-75-4
FormulaC18H24N2O3S
SolubilitySoluble in DMSO
Chemical Name(Z)-3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione
SDFDownload SDF
Canonical SMILESCCCCOC1=CC=C(C=C1)CC/C([H])=C(S2)/C(N(C2=O)CCN)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

K145