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JNJ-7777120

Catalog No.
B1574
Histamine H4 receptor antagonist
Grouped product items
SizePriceStock Qty
5mg
$55.00
In stock
10mg
$85.00
In stock
50mg
$198.00
In stock
100mg
$352.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

JNJ-7777120 (CAS: 459168-41-3) is a potent, selective, non-imidazole antagonist targeting the histamine H4 receptor (IC50 = 4.5 nM, Ki = 4.5 nM), exhibiting over 1000-fold selectivity compared to other histamine receptor subtypes. In vitro studies demonstrate high affinity binding specifically to human H4 receptors without notable interaction among over 50 tested alternate molecular targets. In animal models, JNJ-7777120 displays oral bioavailability (rat ~30%, dog ~100%) and approximately 3-hour half-life. It inhibits histamine-induced mast cell migration and neutrophil infiltration, suggesting utility in inflammation-related biomedical research.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt277.75
Cas No.459168-41-3
FormulaC14H16ClN3O
Solubilityinsoluble in H2O; ≥15.93 mg/mL in EtOH; ≥94.6 mg/mL in DMSO
Chemical Name(5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone
SDFDownload SDF
Canonical SMILESCN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

JNJ-7777120