JNJ-7777120
Catalog No.
B1574
Histamine H4 receptor antagonist
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JNJ-7777120 (CAS: 459168-41-3) is a potent, selective, non-imidazole antagonist targeting the histamine H4 receptor (IC50 = 4.5 nM, Ki = 4.5 nM), exhibiting over 1000-fold selectivity compared to other histamine receptor subtypes. In vitro studies demonstrate high affinity binding specifically to human H4 receptors without notable interaction among over 50 tested alternate molecular targets. In animal models, JNJ-7777120 displays oral bioavailability (rat ~30%, dog ~100%) and approximately 3-hour half-life. It inhibits histamine-induced mast cell migration and neutrophil infiltration, suggesting utility in inflammation-related biomedical research.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 277.75 |
| Cas No. | 459168-41-3 |
| Formula | C14H16ClN3O |
| Solubility | insoluble in H2O; ≥15.93 mg/mL in EtOH; ≥94.6 mg/mL in DMSO |
| Chemical Name | (5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone |
| SDF | Download SDF |
| Canonical SMILES | CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
