Ivermectin B1a
Catalog No.
C3905
main component of the anthelmintic, ivermectin;glutamate-gated chloride channels opener
Featured Products
Ivermectin B1a (CAS 71827-03-7) is the primary constituent (≥80%) of the antiparasitic macrocyclic lactone, ivermectin. Its pharmacological effects originate from selective interaction with glutamate-gated chloride ion channels prevalent in neurons and pharyngeal muscles of nematodes. This binding induces durable chloride influx, causing sustained hyperpolarization or depolarization, resulting in neuromuscular paralysis. Ivermectin displays potent antiparasitic efficacy (EC?? ≈104 nM) and is clinically significant in treating human onchocerciasis, reducing symptoms associated with the infection.
| Physical Appearance | A white solid |
| Storage | Store at -20°C |
| M.Wt | 875.1 |
| Cas No. | 71827-03-7 |
| Formula | C48H74O14 |
| Synonyms | dihydro Avermectin B1a,22,23-dihydro Avermectin B1a |
| Solubility | Soluble in DMSO |
| Chemical Name | 5-O-demethyl-22,23-dihydro-avermectin A1a |
| SDF | Download SDF |
| Canonical SMILES | C/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C(CO3)/[C@@]([C@@]3([H])[C@H](O)C(C)=C4)(O)[C@]4([H])C5=O)=C\C[C@]6([H])C[C@@](O5)([H])C[C@]7(CC[C@H](C)[C@]([C@H](CC)C)([H])O7)O6 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
