Isoquercitrin

Isoquercitrin (CAS No.: 482-35-9) is a naturally occurring polyphenolic flavonoid, primarily derived from the plant Bidens bipinnata L., and is known for its multi-faceted role in biomedical research and drug discovery. Functioning as an antioxidant, Isoquercitrin mitigates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses through the activation of the Nrf2/ARE antioxidant signaling pathway. Additionally, it modulates the expression of nitric oxide synthase 2 (NO2) via the regulation of the nuclear factor-κB (NF-κB) transcription system. As an inhibitor of the Wnt/β-catenin pathway, it impedes downstream nuclear translocation of β-catenin, positioning it as a potential anti-tumoral agent against cancers associated with opioid receptors and the MAPK signaling pathway. Its anticancer activity, demonstrated in cellular models, suggests efficacy in low micromolar concentrations, although specific IC50 values in vitro remain to be comprehensively documented. Research involving Isoquercitrin has explored its potential in bone mineralization, highlighting its relevance in osteoporotic disorder prophylaxis, and hinted at applications in neurodegenerative conditions such as Parkinson's disease. The compound's high bioavailability and low toxicity exemplify its value as a promising research molecule in the exploration of metabolic and signaling pathways, with broad applicability across cell and animal models, typically tailored to experimental designs and objectives.