Irinotecan HCl Trihydrate
Catalog No.
B2293
Topoisomerase 1 inhibitor
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Irinotecan HCl Trihydrate (CAS 136572-09-3), also known as CPT-11, is a semisynthetic derivative of camptothecin designed to improve therapeutic efficacy while reducing toxicity. It acts as a soluble prodrug, which undergoes enzymatic cleavage by carboxylesterases in vivo to yield SN-38, a potent inhibitor of topoisomerase I. CPT-11 exhibits cytotoxicity against leukemia (P388) cell lines with an IC50 of 3.4 μM, and demonstrates antitumor activity in vitro and in vivo against both drug-sensitive and multidrug-resistant tumor models. It is FDA-approved for treating metastatic colorectal cancer following progression after fluorouracil-based therapies.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 677.18 |
| Cas No. | 136572-09-3 |
| Formula | C33H45ClN4O9 |
| Solubility | ≥23.1 mg/mL in DMSO; insoluble in EtOH; ≥2.5 mg/mL in H2O with gentle warming and ultrasonic |
| Chemical Name | (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate |
| SDF | Download SDF |
| Canonical SMILES | O=C(N1CCC(CC1)N2CCCCC2)OC3=CC4=C(CC)C5=C(C(N6C5)=CC(C7(CC)O)=C(COC7=O)C6=O)N=C4C=C3.Cl.O.O.O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
