Iopromide

Iopromide (CAS No.: 73334-07-3) is a non-ionic, monomeric, iodine-based contrast agent widely employed in biomedical research as a water-soluble X-ray imaging medium for intravascular administration. Classified within iodinated radiographic contrast compounds, it is characterized by favorable physicochemical stability and imaging performance, making it a standard tool for enhancing vascular and tissue contrast in preclinical and clinical imaging studies. Although not primarily developed as a targeted therapeutic, Iopromide has been reported to influence cellular responses through modulation of signaling pathways and potential effects on enzyme activity, particularly in the context of endothelial function and renal tubular stress. Its biological effects are most prominently associated with contrast-induced nephropathy, where it is used experimentally to model acute kidney injury in vitro and in vivo, supporting investigations into oxidative stress, inflammation, and apoptosis pathways. Activity in these systems is typically observed at concentrations ranging from micromolar to millimolar levels, depending on the model and endpoint assessed. In research settings, Iopromide is extensively utilized in vascular imaging, cardiovascular disease studies, and nephrotoxicity models, with dosing and exposure conditions tailored to specific experimental designs to evaluate imaging efficacy, tissue distribution, and contrast-related biological effects.