Inositol nicotinate

Inositol nicotinate (CAS No.: 6556-11-2) is a synthetic ester derived from inositol and nicotinic acid, widely utilized as a biochemical reference compound in studies of vascular biology and lipid metabolism. It is characterized by its ability to undergo gradual hydrolysis, releasing free nicotinic acid and thereby modulating signaling pathways associated with vasodilation, including mechanisms linked to prostaglandin-mediated vascular smooth muscle relaxation and enhanced peripheral blood flow. In experimental systems, inositol nicotinate has been shown to influence lipid homeostasis, with reported effects on cholesterol regulation, although its impact on triglyceride levels appears limited in certain induced animal models. As a research tool, it is applied in investigations of endothelial function, peripheral circulation, and metabolic regulation, as well as in pharmacological profiling and mechanistic studies related to atherosclerosis and vascular dysfunction. In vitro and in vivo studies typically employ concentrations or dosing regimens tailored to specific assay conditions, with observed biological activity generally occurring across low micromolar to millimolar ranges depending on the experimental model. This compound is suitable for use in cell-based assays, animal studies, and drug discovery workflows aimed at elucidating pathways involved in vascular responsiveness and lipid metabolism.